Figure 1 | Scientific Reports

Figure 1

From: MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy

Figure 1

Plasma miR-130b downregulation contributes to increased tubulointerstitial fibrosis and unfavorable renal function in diabetic nephropathy (DN) patients.

(a) Decreased plasma miR-130b in 27 DN patients compared with 20 healthy controls. (b) Increased BUN, serum creatinine, β2-microglobulin, blood glucose, blood pressure and urine albumin in 27 DN patients compared with 20 normal controls using Mann-Whitney U-test. (c) Pearson correlation analysis demonstrated the inverse correlations of plasma miR-130b with serum creatinine, (d) β2-microglobulin and (e) proteinuria in 27 DN patients, respectively. (f) Upregulation of SNAIL, VIMENTIN, COLLAGEN IV and α-SMA but downregulation of E-CADHERIN by immunohistochemistry and quantification of the staining intensity in 86 renal biopsy samples compared with 20 normal controls. (g) Increased renal tubulointerstitial fibrosis in DN patients by MTS and the quantification analysis. Results are presented as mean ± SD of three independent experiments. #P < 0.0001. NC, normal control; DN, diabetic nephropathy; MTS, Masson’ s trichrome stain.

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