Figure 2 | Scientific Reports

Figure 2

From: MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy

Figure 2

SNAIL negatively correlates with E-CADHERIN and corresponded with increased renal tubulointerstitial fibrosis in DN.

(a) Immunofluorescence staining of SNAIL and E-CADHERIN in renal tubules of 20 normal controls and (b) 42 snap-frozen DN samples. (c) Magnified images of the boxed area showing increased E-CADHERIN expression. (d) Yellow color represents the co-localization between SNAIL and E-CADHERIN (arrows). (e) Increased renal tubulointerstitial fibrosis and increased interstitial injury score in DN compared with NC by MTS. Results are presented as mean ± SD of three independent experiments. #P < 0.0001. NC, normal control; DN, diabetic nephropathy; MTS, Masson’ s trichrome stain.

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