Figure 3 | Scientific Reports

Figure 3

From: Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation

Figure 3

The effect of surface roughness and demineralized bone matrix on bone growth and mechanical properties of new bone growth into porous disks.

Laser sintered implants were manufactured and polished or treated by blasting and acid etching to produce smooth and rough surfaces for calvarial implantation in rats. Laser confocal microscopy confirmed reduced surface roughness and peak to valley heights (A) of smooth surfaces (A top right) in comparison to rough surfaces (A bottom right). MicroCT image analysis (B) was conducted of calvarial implants after 10 weeks to assess bone-to-implant contact (C) and bone ingrowth in holes (D). SEM micrographs after pull-out testing of the implant ((E–G) top, with inset optical images) and calvaria ((E–G) bottom, with inset optical images) showed bone growth and attachment to implants. Pull out testing revealed force at failure (H) and modulus (I) 10 weeks after implantation. Force at failure for pull out testing (J) and modulus (K) was also compared at 5 and 10 weeks for the DBX treated group. One-way ANOVA with Bonferroni correction, p < 0.05, * vs. smooth or week 5, ^ vs. rough.

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