Table 1 Correlations of HER2 or Snail expression with Clinicopathologic Factors.
Characteristics | No. of cases | HER2-positive-FISH (%) | HER2-positive-IHC (%) | Snail-positive(%) |
|---|---|---|---|---|
Gender | ||||
Male | 272 | 51 (18.6) | 50 (18.4) | 109 (40.1) |
Female | 110 | 27 (24.5) | 26 (23.6) | 54 (49.1) |
p value | 0.203 | 0.244 | 0.107 | |
Age (yrs) | ||||
≤59 | 192 | 33 (17.2) | 33 (17.2) | 74 (38.5) |
>59 | 190 | 45 (23.7) | 43 (22.6) | 89 (46.8) |
p value | 0.115 | 0.183 | 0.101 | |
Size (cm) | ||||
≤4 | 185 | 36 (19.5) | 35 (18.9) | 57 (30.8) |
>4 | 197 | 42 (21.3) | 41 (20.8) | 106 (53.8) |
p value | 0.652 | 0.643 | 0 | |
TNM stage | ||||
I/II | 163 | 15 (9.2) | 15 (9.2) | 24 (14.7) |
III/IV | 219 | 63 (28.8) | 61 (27.9) | 139 (63.5) |
p value | 0 | 0 | 0 | |
Depth of invasion | ||||
pT1 & pT2 | 138 | 18 (13.0) | 19 (13.8) | 24 (17.4) |
pT3 | 244 | 60 (24.6) | 57 (23.4) | 139 (57.0) |
p value | 0.007 | 0.024 | 0 | |
Differentiation | ||||
WD & MD | 109 | 25 (22.9) | 25 (22.9) | 34 (31.2) |
PD | 273 | 53 (19.4) | 51 (18.7) | 129 (47.3) |
p value | 0.441 | 0.347 | 0.004 | |
LN metastasis | ||||
Negative | 138 | 13 (9.4) | 13 (9.4) | 23 (16.7) |
Positive | 244 | 65 (26.6) | 63 (25.8) | 140 (57.4) |
p value | 0 | 0 | 0 | |
Vascular invasion | ||||
Negative | 156 | 13 (8.3) | 13 (8.3) | 26 (16.7) |
Positive | 226 | 65 (28.8) | 63 (27.9) | 137 (60.6) |
p value | 0 | 0 | 0 | |
Metastasis | ||||
Negative | 324 | 59 (18.2) | 57 (17.6) | 117 (36.1) |
Positive | 58 | 19 (32.8) | 19 (32.8) | 46 (79.3) |
p value | 0.011 | 0.008 | 0 | |
Positive Rate | 20.4% | 19.9% | 42.7% | |
