Figure 2 | Scientific Reports

Figure 2

From: Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways

Figure 2

Miltirone has a potential of antitumor effect and low toxicity in vivo.

The transplanted mice U937 leukemias were treated with 15 mg/kg of miltirone by i.p. every other day. Control group was treated with vehicle. (a) Tumor volume was measured every four days. (b) Tumor mass were weighed. (c) Tumors were fixed and stained with hemtoxylin and eosin (H&E) stain to examine tumor cell morphology, using TUNEL assay to determine apoptosis. (d) Body weight of mice during the 20 days of miltirone treatment. (e) H&E stained main organs of mice from treated and control sets to evaluate the toxicity of miltirone. Data were presented as Mean ± SD, n = 6. The differences were significant at *p < 0.05, **p < 0.01 vs. control.

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