Figure 2

Heat map of Spearman correlation coefficients between AAs and metabolic markers (a), relationship between combined score and HOMA-IR (b), Scatter plot of combined score (c) and HOMA-IR (d) in HL, OW/OB, and DM individuals from cross sectional study. Abbreviations used: ALT, alanine aminotransferase; AST, aspartate aminotransferase; Score, the first decomposed principal component derived from the abundance of the five AAs; DM, overweight or obesity with type 2 diabetes; DP, diastolic blood pressure; γ-GT, gamma-glutamyl trans-supeptidase; Glucose0, fasting glucose; Glucose120, 2 h glucose; HDL, high-density lipoprotein-cholesterol; HL, healthy lean; HOMA-Beta = 20*INS0/(Glucose0-3.5); HOMA-IR = Glucose0*Glucose120/22.5; INS0, fasting insulin; INS120, 2 h insulin; Isoleu, isoleucine; LDL, low-density lipoprotein-cholesterol; Leu, leucine; Matsuda index = 10000/(Glucose0*Glucose120*INS0*INS120)1/2; OW/OB, healthy overweight or obesity; Phenyl, phenylalanine; SP, systolic blood pressure; TC, total cholesterol; TG, triglyceride; Tyro, tyrosine; Val, valine.