Figure 8 | Scientific Reports

Figure 8

From: Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1

Figure 8

DNA-GLI-QC ternary complex after equilibration run of 1 ns.

(a) Dynabead mediated GLI-DNA complex pull down assay after treatment with NQC. (b) Acridine ring of QC is inserted between the GC base pairs. (c) Interaction diagram of QC in DNA-GLI complex. Yellow cylindrical contacts represent π-π interactions and spheres represent the hydrogen bonding interaction (d) The hydrogen bond (between DNA and Protein) occupancy analysis for the binary (DNA-GLI, blue) and ternary (DNA-GLI-QC, red) complexes. The residues in boxes are forming hydrogen bonds in the crystal structure (PDB ID: 2GLI).

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