Figure 9 | Scientific Reports

Figure 9

From: Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1

Figure 9

NQC caused apoptosis through HH-GLI dependent manner in PEMT-Hela (cervical CSCs) xenograft mice model at a dose 40 mg/kg/day (a) Average tumor size of NQC treated mice. (♦), (♦) and (▴) represents PBS control, tumor and NQC treated tumor xenografts. (b) Expressions of proteins in tumor lysates. Data presented here is the mean ± SD of three independent experiments. Statistical significance was determined by paired t test (***p < 0.001). (c) Expressions of proliferation marker Ki-67 in xenografts mice model. Data presented here is mean ± SD of three independent experiments. (d) H&E staining of the xenograft tissue section. Scale bar 20 μm. The data is the representative image of three independent experiments. (e) Immunohistochemical expression of GLI-1. Scale bar 40 μm. Data is the representative image of three independent experiments.

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