Figure 2: Schematic diagram of the path analyses for frontal cortical thickness. | Scientific Reports

Figure 2: Schematic diagram of the path analyses for frontal cortical thickness.

From: Albuminuria, Cerebrovascular Disease and Cortical Atrophy: among Cognitively Normal Elderly Individuals

Figure 2

Elevated urine albumin to creatinine ratio (UACR) was associated with moderate to severe white matter hyperintensities (WMH), which were further associated with frontal cortical thinning. Elevated UACR was also associated with frontal thinning without being mediated by WMH burdens. Albuminuria was entered as a predictor and WMH volume was entered as a mediator. Age, sex, history of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, and stroke, fasting glucose, systolic blood pressure, diastolic blood pressure, total cholesterol level, body mass index, status of current smoking and alcohol drinking, education level and intracranial volume were entered as covariates. Numbers on the paths are standardized coefficients that were statistically significant.

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