Figure 4: Specificity of cancer hallmark classes.
From: Cell type-specific properties and environment shape tissue specificity of cancer genes
(A) DNA repair genes (n = 8) are significantly (*p < 0.05; **p < 0.01; Wilcoxon-Mann-Whitney test) more specific than genes from the other cancer hallmark classes of oncogenes (n = 25) and tumor suppressors (n = 18). (B) The distribution of cancer-related DNA repair pathway genes differs between tissues. (C) Principal component projection of cancer tissues in DNA repair pathway space. The red arrows show the original axes in the new space.
