Table 2 Associations between cerebrovascular disease, Aβ isoforms and amyloid PET per diagnostic group.

Group	Parameter	WML volume ± 95% CI			Fazekas score ± 95% CI			Lacunes ± 95% CI
Cognitively	CSF Aβ38	−0.151 ^**	−0.260	−0.042	−0.071	−0.191	0.048	−0.254	−1.369	0.861
healthy	CSF Aβ40	−0.118 ^*	−0.228	−0.008	−0.058	−0.178	0.061	−0.363	−1.940	1.213
elderly	CSF Aβ42	−0.075	−0.185	0.036	0.017	−0.103	0.137	−0.795	−2.406	0.815
	Composite SUVR	0.037	−0.137	0.210	−0.057	−0.241	0.127	0.570	−2.911	4.052
Subjective	CSF Aβ38	−0.211 ^**	−0.341	−0.081	−0.170 ^*	−0.312	−0.028	2.306	−0.317	−0.030
cognitive	CSF Aβ40	−0.243 ^***	−0.371	−0.115	−0.197 ^**	−0.337	−0.057	1.144	−0.309	−0.020
deficit	CSF Aβ42	−0.079	−0.213	0.055	−0.066	−0.211	0.079	0.976	−0.154	0.142
	Composite SUVR	0.099	−0.075	0.273	0.070	−0.118	0.257	−0.686	−0.187	0.231
Mild	CSF Aβ38	−0.264 ^***	−0.396	−0.133	−0.174 ^*	−0.317	−0.030	−1.947 ^*	−3.655	−0.239
cognitive	CSF Aβ40	−0.286 ^***	−0.417	−0.155	−0.164 ^*	−0.309	−0.020	−1.018	−2.312	0.276
impairment	CSF Aβ42	0.000	−0.138	0.138	−0.006	−0.154	0.142	0.715	−0.501	1.931
	Composite SUVR	−0.028	−0.226	0.170	0.022	−0.187	0.231	0.149	−2.755	3.052
PD−patients	CSF Aβ38	−0.181 ^**	−0.310	−0.053	−0.188 ^*	−0.365	−0.011	NA
	CSF Aβ40	−0.185 ^**	−0.314	−0.056	−0.175	−0.225	−0.125	NA
	CSF Aβ42	−0.066	−0.204	0.072	0.010	0.386	−0.366	NA
AD−patients	CSF Aβ38	NA			−0.258 ^*	−0.447	−0.070	NA
	CSF Aβ40	NA			−0.299 ^**	−0.485	−0.113	NA
	CSF Aβ42	NA			−0.225 ^*	−0.413	−0.038	NA

Values represent standardized beta (linear regression, WML volume and total Fazekas score) and Beta (logistic regression, lacunes) with 95% confidence intervals; prior to analysis, the natural logarithm of parameters was calculated where appropriate in order to ensure normal distribution. Values are corrected for age, gender and hippocampal volume; the latter was determined using Adaboost, the mean value of the left and right hippocampus was normalized using the scaling factor provided by this software to account for head size differences.
In the PD and AD groups, 2.3% and 3.6% of the subjects had lacunes and the association between CSF Aβ species and lacunes was not analyzed. Data on WML volume were not available for the AD group, where imaging mainly was performed using CT.
*p < 0.05, **p < 0.0125, ***p > 0.001.
Only p−values < 0.0125 should be considered significant according to Bonferroni−adjustment.

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