Table 3 Associations between SVD, estimated as the volume of white matter lesions (WML), the total score of WML according to Fazekas, and lacunes, and amyloid isoforms in CSF and amyloid PET, in the pooled CHE, SCD and MCI subgroups.

Group	Parameter	WML volume ± 95% CI			Fazekas ± 95% CI			Lacunes ± 95% CI
All CHE, SCD	CSF Aβ38	−0.219 ^***	−0.288	−0.15	−0.150 ^***	−0.227	−0.073	−0.841	−1.966	0.284
and MCI	CSF Aβ40	−0.205 ^***	−0.274	−0.136	−0.128 ^***	−0.205	−0.051	−0.418	−1.253	0.417
	CSF Aβ42	−0.086 ^*	−0.158	−0.014	−0.055	−0.135	0.025	0.298	−0.513	1.109
	Composite SUVR	0.074	−0.031	0.179	0.071	−0.044	0.186	−0.12	−1.723	1.483
APOE ε4 −	CSF Aβ38	−0.282 ^***	−0.394	−0.17	−0.203 ^**	−0.328	−0.078	−2.354 ^**	−4.104	−0.604
positive	CSF Aβ40	−0.266 ^***	−0.381	−0.071	−0.154 ^*	−0.277	−0.031	−1.544 ^*	−2.879	−0.209
CHE, SCD	CSF Aβ42	−0.127 ^*	−0.247	−0.007	−0.09	−0.221	0.041	0.971	−0.278	2.22
and MCI	Composite SUVR	0.153	−0.031	0.337	0.103	−0.105	0.311	−1.128	−3.842	1.598
APOE ε4 −	CSF Aβ38	−0.187 ^***	−0.276	−0.098	−0.125 ^*	−0.224	−0.026	0.229	−1.292	1.75
negative	CSF Aβ40	−0.174 ^***	−0.263	−0.085	−0.117 ^*	−0.216	−0.018	0.314	−0.776	1.404
CHE, SCD	CSF Aβ42	−0.128 ^**	−0.22	−0.036	−0.086	−0.188	0.016	0.054	−1.275	1.383
and MCI	Composite SUVR	0.08	−0.052	0.213	0.06	−0.084	0.204	0.432	−1.969	2.833

Values represent standardized beta (linear regression, WML volume and total Fazekas score) and Beta (logistic regression, lacunes) with 95% confidence intervals; prior to analysis, the natural logarithm of parameters was calculated where appropriate in order to ensure normal distribution. Values are corrected for age, gender and hippocampal volume; the latter was determined using Adaboost, the mean value of the left and right hippocampus was normalized using the scaling factor provided by this software to account for head size differences.
*p < 0.05, **p < 0.0125, ***p > 0.001.
Only p-values < 0.0125 should be considered significant according to Bonferroni-adjustment.

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