Table 1 The variability of coefficients for each reaction moiety over time after exposure of Zs + cells (cancer stem calls) and Zs− cells (non cancer stem cells) to anti-tumour agents.

From: A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells

 

Time point (h)

 

0

24

72

CV error

Reaction moiety

 Putrescine

  Zs+

   ODC1

3.93E-04

−5.87E−05

4.53E-05

 

   SRM

−4.33E−04

−8.29E−04

−1.16E−04

1.67E-09

   SAT1

−6.59E−06

1.16E-05

1.24E-04

 

  Zs−

   ODC1

1.00E-05

1.89E-04

3.07E-04

 

   SRM

−3.22E−05

−4.02E−04

−6.73E−04

3.78E-11

   SAT1

1.56E-04

5.47E-05

2.35E-05

 

 Spermidine

    

  Zs+

    

   SRM

1.69E-06

−4.44E−05

1.53E-05

 

   SAT2

1.15E-05

−1.12E−04

3.67E-07

8.84E-13

   SAT1

−3.23E−04

−2.25E−04

−1.37E−04

 

   SMS

−4.51E−05

−1.16E−04

−8.62E−06

 

  Zs−

   SRM

6.12E-05

2.48E-06

1.15E-05

1.67E-12

   SAT2

−1.03E−05

1.97E-03

1.12E-06

 

   SAT1

−3.39E−04

−1.27E−04

−1.33E−04

 

   SMS

−5.85E−05

−7.35E−04

−7.76E−06

 

 Spermine

  Zs+

   SMS

1.95E-09

1.07E-05

9.49E-05

8.03E-15

   SAT2

−6.13E−03

−4.50E−03

−5.04E−04

 

  Zs−

   SMS

5.13E-09

7.63E-05

6.43E-10

2.79E-15

   SAT2

−4.85E−03

−4.57E−03

−3.95E−03

 
  1. CV errors are shown for each cell.
  2. CV, cross-validation; ODC, ornithine decarboxylase; SAT2, spermine N1-acetyltransferase 2; SMS, spermine synthase.
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