Figure 2: Carbachol inhibition of Isc in primary cultures of human bronchial epithelial cells.
From: Inhibition of airway surface fluid absorption by cholinergic stimulation
Top trace: ENaC-dependent Isc is partially inhibited by 1 mM carbachol and reduced to zero with 10 μM benzamil. Both kinds of inhibition were partially reversed by washing. Bottom trace: all Isc was inhibited by benzamil but not by carbachol. Unlike animal tracheas, an initial transient Isc increase to 1 mM carbachol was either small or absent in HBE cells (n = 9 monolayer inserts).
