Figure 5
From: ITF2357 transactivates Id3 and regulate TGFβ/BMP7 signaling pathways to attenuate corneal fibrosis
ITF2357 attenuates pro-fibrotic proteins.
Extracellular matrix proteins (↑) (A–D) collagen I, (E–H) collagen IV, (I–L) fibronectin, (M–P) integrin αVβ3 were upregulated in (B,F,J,N) 4 wk post-PRK corneas. Collagen I and integrin αVβ3 staining was reduced in (C,O) ITF2357 and (D,P) MMC treated corneas. Similar reduction levels of collagen IV and fibronectin expression was observed in (G,H,K,L) post-PRK corneas treated with drugs. There were n = 4 samples in each group and scale bar = 50 μm.
