Table 4 Correlation analysis and multivariate linear regression analysis for changes in PWV.

	ΔbaPWV_0-6mo				ΔhaPWV_0-6mo
	Correlation coefficient	P value	Multivariate regression, adjusted R² = 0.514		Correlation coefficient	P value	Multi-variable regression, adjusted R² = 0.618
	Correlation coefficient	P value	β (95% C.I)	P value	Correlation coefficient	P value	β (95% C.I)	P value
Age, years	0.051	0.61			0.114	0.277
Gender	0.113	0.697			-0.027	0.801
LVH	−0.176	0.114			−0.169	0.139
Hypertension history, years	−0.094	0.352			0.02	0.848
No. of anti-hypertensive medication	−0.19	0.853			−0.013	0.9
Use of ACEI	−0.029	0.775			0.026	0.807
Use of clonidine	−0.73	0.464			−0.053	0.614
Potassium, mmol/L	0.035	0.73			0.041	0.696
Creatinine, mg/dL	−0.032	0.754			0.079	0.453
Log PAC	−0.221	0.026			−0.194	0.062
Log PRA	−0.015	0.879			0.082	0.44
Log ARR	0.015	0.905			−0.097	0.462
SBP, mmHg	−0.272	0.006			−0.267	0.01
DBP, mmHg	−0.274	0.005			−0.281	0.006
PWV_pre#	−0.5	<0.001	−0.292 (−0.404~ −0.179)	<0.001	−0.525	<0.001	−0.242 (−0.373~ −0.111)	<0.001
ΔLog PAC_0-6mo	0.229	0.032			0.282	0.012
ΔLog PRA_0-6mo	−0.156	0.15			−0.239	0.035	−23.718 (−43.297~ −4.14)	0.018
ΔLog ARR_0-6mo	0.088	0.515			0.162	0.231
ΔSBP_0-6mo	0.579	<0.001			0.692	<0.001
ΔDBP_0-6mo	0.597	<0.001	9.137 (6.279~11.996)	<0.001	0.742	<0.001	5.781 (4.309~7254)	<0.001

Values are mean ± SD. ΔbaPWV_0-6mo = the decrease in baPWV at 6 months; ΔhaPWV_0-6mo = the decrease in haPWV at 6 months; BMI = body mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure; ACEI = angiotensin converting enzyme inhibitor; LVH = left ventricular hypertrophy; Log PAC = log-transformed plasma aldosterone concentration; Log PRA = log-transformed plasma renin activity; Log ARR = log-transformed aldosterone to renin ratio; ΔLog PAC_0-6mo =log-transformed the decrease in plasma aldosterone concentration at 6 months; ΔLog PRA_0-6mo =log-transformed the decrease in plasma renin activity at 6 months; ΔLog ARR_0-6mo =log-transformed the decrease in aldosterone to renin ratio at 6 months; ΔLog SBP_0-6mo =log-transformed the decrease in systolic blood pressure at 6 months; ΔLog DBP_0-6mo =log-transformed the decrease in diastolic blood pressure at 6 months; # PWV_pre represents baPWVpre in ΔbaPWV_0-6mo analysis and haPWVpre in ΔhaPWV_0-6mo analysis.

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