Table 1 Characteristics of included studies.

From: Diagnostic Accuracy of Transcranial Sonography of the Substantia Nigra in Parkinson’s disease: A Systematic Review and Meta-analysis

Author	Year	Country	PD cases	Age (Ave.)	Diagnostic Criteria	TCS device	Cut-off value	TP	FP	FN	TN	QUADAS score
Stenc Bradvica I	2015	Italy	59	67.2	UK Brain Criteria	2–4 MHz	20 mm²	37	6	22	20	11
Maria Sierra	2013	Spain	68	68.93	UK Brain Criteria	2.5 MHz	20 mm²	65	7	3	39	10
Sinem Tunc	2015	Germany	53	73.92	UK Brain Criteria	2–2.5 MHz	25 mm²	40	21	13	207	10
M. O. Izawa	2011	Japan	33	64.8	UK Brain Criteria	2 MHz	16 mm²	26	2	7	30	9
Hee Young Shin	2011	Korea	24	62.3	UK Brain Criteria	2.5 MHz	20 mm²	21	4	3	21	11
Tobias Bottcher	2013	Germany	12	60.9	UK Brain Criteria	2.5 MHz	24 mm²	10	4	2	28	10
Christoph Schmidauer	2005	Austria	20	64	UK Brain Criteria	2.5 MHz	20 mm²	19	5	1	15	10
Pavel Ressner	2007	Czech	47	64.7	UK Brain Criteria	2–3 MHz	19 mm²	41	2	6	37	11
Heike Stochner	2007	Austria	100	65.2	UK Brain Criteria	2.5 MHz	24 mm²	75	3	25	97	10
Panteha Fathinia	2012	Germany	31	63.5	UK Brain Criteria	3 MHz	20 mm²	26	3	5	70	10
Kristina Lauckaitel	2012	Lithuania	71	63.8	UK Brain Criteria	1.3–4 MHz	20 mm²	66	8	5	63	11
Edson Bor–Seng–Shu	2014	Brazil	20	62.5	UK Brain Criteria	2–3 MHz	22 mm²	20	2	0	7	10
U. Walter	2001	Germany	30	68.9	UK Brain Criteria	2.5 MHz	20 mm²	30	7	0	23	10
Philipp Mahlknecht	2013	Austria	17	81.8	UK Brain Criteria	2.5 MHz	18 mm²	15	103	2	344	9
Do–Young Kwon	2010	Korea	63	64.6	UK Brain Criteria	2.5 MHz	20 mm²	51	5	12	35	11
Yu–Wen Huang	2007	Chinese Taipei	80	59.1	UK Brain Criteria	2.25 MHz	20 mm²	54	6	26	114	11
Rita de Cassia	2011	Brazil	17	66.9	UK Brain Criteria	1.6–2.5 MHz	20 mm²	15	2	2	9	9
Sabine Mehnert	2010	Germany	183	66	UK Brain Criteria	1.8–3.6 MHz	20 mm²	173	8	10	193	10
Nikola Kresojevi	2012	Germany	54	61.5	None	2.5 MHz	19 mm²	46	5	8	48	11
Wei–Feng Luo	2011	China	110	58.7	UK Brain Criteria	None	20 mm²	88	11	22	99	10
Kristina Lauckaite	2014	Lithuania	141	64.4	UK Brain Criteria	None	20 mm²	106	18	35	83	10
Li Chen	2013	China	170	61.3	UK Brain Criteria	1–3 MHz	20 mm²	139	12	31	91	9
Sheng Yujing	2011	China	78	62.2	UK Brain Criteria	2.5 MHz	20 mm²	66	5	12	55	11
Zhang Yingchun	2010	China	80	60.7	UK Brain Criteria	2–2.5 MHz	20 mm²	58	10	22	70	10
Ahmad Chitsaz	2013	Iran	43	63.39	UK Brain Criteria	2–4 MHz	20 mm²	39	4	4	46	11
Jurgen Prestel	2006	Germany	42	64.6	UK Brain Criteria	2.5 MHz	20 mm²	36	6	6	29	11
Ji Youn Kim	2007	Korea	35	56.7	UK Brain Criteria	2–5 MHz	20 mm²	29	2	6	25	10
Jung Ho Ryu	2011	Korea	19	68.5	UK Brain Criteria	2.5 MHz	20 mm²	16	24	3	11	10
Wang Rong	2011	China	34	64.11	UK Brain Criteria	1–5 MHz	20 mm²	31	4	3	34	9
Araceli	2014	Germany	97	67	UK Brain Criteria	2.5 MHz	21 mm²	80	15	17	117	11
Alonso
Canovas
W. Ambrosius	2014	Poland	95	62	UK Brain Criteria	2.5–3.5 MHz	19 mm²	78	10	17	85	11

Age (Ave.): average of age of included PD Patients; TP: true positive; FP: false positive; FN: false negative; TN: true negative.

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Table 1 Characteristics of included studies.

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