Table 2 Canonical pathway analysis using ingenuity pathways analysis (IPA; Ingenuity Systems, www.ingenuity.com).

From: Circadian variations in the liver metabolites of medaka (Oryzias latipes)

Ingenuity Canonical Pathways

−log(p-value)

Ratio (ZT16/ZT4)

Lysine Degradation V

3.8E + 00

2.8E − 01

Adenine and Adenosine Salvage III

3.8E + 00

4.0E − 01

Citrulline-Nitric Oxide Cycle

3.6E + 00

3.6E − 01

Guanine and Guanosine Salvage I

3.0E + 00

4.3E − 01

Morphine Biosynthesis

2.9E + 00

3.8E − 01

Purine Nucleotides Degradation II (Aerobic)

2.8E + 00

2.4E − 01

Salvage Pathways of Pyrimidine Ribonucleotides

2.8E + 00

2.4E − 01

Arginine Biosynthesis IV

2.7E + 00

2.2E − 01

TCA Cycle II (Eukaryotic)

2.7E + 00

2.2E − 01

Purine Nucleotides De Novo Biosynthesis II

2.7E + 00

1.7E − 01

Nicotine Degradation II

2.5E + 00

3.0E − 01

Palmitate Biosynthesis I (Animals)

2.5E + 00

3.0E − 01

Glutathione-mediated Detoxification

2.4E + 00

2.7E − 01

Lysine Degradation II

2.3E + 00

2.5E − 01

Purine Ribonucleosides Degradation to Ribose-1-phosphate

2.3E + 00

2.5E − 01

Glutathione Redox Reactions II

2.3E + 00

5.0E − 01

Superpathway of Citrulline Metabolism

2.3E + 00

1.7E − 01

Glycine Betaine Degradation

2.2E + 00

2.3E − 01

Urea Cycle

2.1E + 00

2.1E − 01