Figure 2 | Scientific Reports

Figure 2

From: LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways

Figure 2

Effects of LPS on angiopoietins/Tie-2 system in the lung.

(A) Western blot analysis demonstrating that treatment of mice with LPS for 12 hours resulted in a significant increase in Ang-2 expression in WT and Sirt3KO mice (*p < 0.05, n = 3–5 mice). (B) Western blot analysis showing that treatment of mice with LPS for 12 hours significantly decrease Tie-2 expression in WT and Sirt3KO mice (*p < 0.05, n = 3–5 mice). (C) Western blot analysis revealing that treatment of mice with LPS for 12 hours led to a significant reduction of Ang-1 expression in WT and Sirt3KO mice (*p < 0.05, n = 3–5 mice). (D) Western blot analysis showing that the expression of Tie-2 was downregulated whereas Ang-2 was upregulated in Sirt3KO mice compared to WT mice. The expression of Ang-1 remained unchanged (n = 3 mice, *p < 0.05).

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