Figure 2 | Scientific Reports

Figure 2

From: Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green

Figure 2

In vivo FMI of necrotic tissues in different mouse models.

(a,b) For both the burn and muscle ischemia necrosis mouse models, FMI could indicate necrotic lesions 12 h after IV injection of ICG. The necrotic tissue and corresponding normal tissue are indicated by the red and green arrows, respectively. (c,d) For the burn necrosis mouse model, the optical efficiency profiles of the necrotic lesion and the normal tissue at 24 h and 9 days post-injection are illustrated in the upper graphs of (c,d), respectively. The SBR; ratio of optical efficiency between necrotic and normal tissues) profiles for 24 h and 9 days are illustrated in the bottom graphs of (c,d), respectively. On the ninth day, the average SBR was 1.58 ± 0.23 for burn lesions. (e,f) For the ischemia necrosis mouse model, the quantitative analysis of the optical efficiency and SBR at 24 h and 9 days post-injection are illustrated in the same layout as shown in (c,d). On the ninth day, the average SBR was 2.17 ± 0.22 for ischemia lesions. Both mouse models suggested the necrosis binding of ICG with a long observation window.

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