Table 2 Distribution of individual alleles and allele combinations in carriage and invasive meningococci.

Allele			Isolates with allele ^a	% Carriage (#) ^b	cc(s) ^c	% Invasive (#) ^b	cc(s) ^c	p-value ^d
modA11			454	13 (28)	18, 32, 53, 116, 269	29 (426)	23, 32, 41/44, 92, 213, 269	<0.0001
modA12			1,135	70 (148)	11, 18, 22, 41/44. 106, 116	67 (987)	11, 18, 22, 23, 41/44, 213, 269	0.3478
modA15			35	12 (25)	92	1 (10)		<0.0001
modB1			465	23 (49)	18, 32, 41/44, 269	28 (416)	18, 22, 32, 41/44, 269	0.1389
modB2			634	28 (60)	11, 18, 22	40 (574)	11, 18, 22, 41/44, 213, 269	0.0018
modB4			97	1 (2)	41/44	6.5 (95)	41/44, 213	0.0004
modD1			315	0 (0)		21 (315)	41/44	<0.0001
modD6			71	8 (17)	18, 22	3 (54)	18, 22, 41/44	0.0014
Allele combination			Isolates with combo ^a	% Carriage (#) ^b	cc(s) ^c	% Invasive (#) ^b	cc(s) ^c	p-value ^d
*modA*	*modB*	*modD*	Isolates with combo ^a	% Carriage (#) ^b	cc(s) ^c	% Invasive (#) ^b	cc(s) ^c	p-value ^d
modA11	–	–	109	9.5 (20)	53, 116	6 (89)	23, 32, 92, 269	0.1743
modA12	–	–	282	19 (40)	22, 106, 116	17 (242)	22, 23, 106, 116, 213,	0.4326
modA15	–	–	28	12 (25)	92	0.2 (3)		<0.0001
modA11	modB1	–	317	2.4 (4)	32, 269	22 (313)	32, 269	<0.0001
modA12	modB1	–	103	15 (31)	41/44	5 (72)	18, 41/44, 269	<0.0001
modA12	modB2	–	257	22 (47)	11, 18	15 (210)	11, 18, 41/44, 213	0.057
modA12	modB4	–	94	1 (2)	41/44	6.5 (92)	41/44, 213	0.0004
modA12	modB2	modD1	286	0 (0)		20 (286)	41/44	<0.0001
modA12	modB2	modD6	45	3 (7)	22	3 (38)	18, 22, 41/44	0.6514

^aTotal number in the dataset with each of the most frequent modA, modB and modD alleles, or allele combinations. (−) indicates the mod gene is absent.
^b% (total number) of carriage or invasive isolates with the mod allele or allele combination, calculated as a proportion of total carriage or invasive isolates, respectively. For these analyses, alleles/isolates were included if full allele data was available, and if the allele was considered to encode a potentially functional methyltransferases (i.e., contained no point mutations or insertions/deletions (other than insertions/deletions in the phase variable repeat region); e.g., an allele profile of modA11 - modB1::IS1301 was considered to only contain a putatively functional modA11). Total number of isolates included in analyses: 211 carriage and 1478 invasive isolates for allele distribution; 211 carriage and 1448 invasive isolates for allele combinations (30 invasive isolates removed due to incomplete allele combination data).
^cPredominant clonal complexes containing the allele or allele combination. Clonal complexes are only included if they contain >10 isolates in the database. Sequence types not assigned to a clonal complex are excluded.
^dp-value for the association of the given the allele or allele combination with either carriage or invasive isolates, calculated using the Fisher’s Exact test (two-tailed).

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