Figure 2: Electroretinograms from control and diabetic rats.
From: Light adaptation does not prevent early retinal abnormalities in diabetic rats
Left panels show representative ERG waveforms from rats diabetic for 12 weeks (red traces) and aged-matched controls (black traces) housed under standard lighting conditions. Right panels show summary intensity-response relations. (a,b) Light-adapted retinas. Responses in (a) are to a flash at 2.17 log cd.s/m2. b-Wave amplitudes are shown in (b). (c,d) Dark-adapted retinas. Responses in (c) are to a flash at 1.50 log cd.s/m2. b-Wave amplitudes are shown in (d). (e,f) Oscillatory potentials. Responses in (e) are to a flash at 1.50 log cd.s/m2. The sum of the oscillatory potentials time-to-peak (TTP) for OP1 through OP4 are shown in (f) In the right panels, rats diabetic for 6 and 12 weeks (Db) and aged-matched controls (Ctrl), housed under standard light conditions (0 lux, continuous traces) or dim-adapted at night conditions (3 lux, dashed traces) are shown. Diabetic rats had reduced b-wave amplitudes and increased latency of OPs at both 6 and 12 weeks of diabetes, compared to controls. Housing conditions (standard vs. dim-adapting) did not affect b-wave amplitude or oscillatory potential delay. Numbers in parentheses indicate number of rats. §, not significant for comparison among diabetic groups; *P < 0.05, for comparison between each diabetic group and aged-matched control. ##P < 0.01 and ###P < 0.001 for comparison between standard diabetic rats at 6- and 12-weeks. xP < 0.05 and xxxP < 0.001 for comparison between control groups at 6- and 12-weeks (standard in (b), and dim-adapted in (d)).
