Figure 4: Cell death in control and diabetic retinas.
From: Light adaptation does not prevent early retinal abnormalities in diabetic rats
(a) TUNEL staining in retinal cross-sections from rats diabetic for 6 weeks and aged-matched controls, housed under standard lighting conditions. DAPI-labelled nuclei (blue) and a TUNEL-positive cell (blue/green; arrow) are shown. Scale bar: 50 μm. (b) Mean number of TUNEL-positive cells from 12-micron-thick retinal sections through the optic disc, normalized to the length of the retinal slice. (c) Total retinal thickness in control (Ctrl) and diabetic rats (Db), housed under standard (0 lux) or dim-adapted at night (3 lux) conditions. Numbers in parentheses indicate number of rats. *P < 0.05, ***P < 0.001 vs age-matched control; #P < 0.05 comparison between dim-adapted diabetic rats at 6- and 12-weeks.
