Figure 1 | Scientific Reports

Figure 1

From: Treatment of beta amyloid 1–42 (Aβ1–42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo

Figure 1

Effect of administering Aβ1–42 to NBM on loss of cholinergic cells and fibers.

Histogram shows the percentage of ChAT- and AChE-positive cell and fiber loss 12d after administration of different Aβ1–42 concentrations (A,B) and at various survival times after a fixed concentration (20 μM) of Aβ1–42 (C,D). ChAT immunolabeled cell bodies in the NBM (E,F) and AchE-positive fibers in layer IV and V of the somatosensory cortex (G,H) at the non-treated (E,G) and Aβ1–42-treated brain side (F,H). Scale bars, 50 μm; inserts 25 μm. Histograms show mean ± SEM (n = 4–9). ***P < 0.001 (one way ANOVA with post hoc Bonferroni test).

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