Figure 1: High levels of Stat3 activation and increased HO-1 expression are preferentially associated with abnormal keratinocyte differentiation and overproliferation in psoriatic lesional skin. | Scientific Reports

Figure 1: High levels of Stat3 activation and increased HO-1 expression are preferentially associated with abnormal keratinocyte differentiation and overproliferation in psoriatic lesional skin.

From: Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling

Figure 1

Formalin-fixed paraffin-embedded tissue sections from psoriasis patients and healthy individuals were examined by histopathological assay. (a) H&E staining of normal skin and psoriatic lesional skin. (b) Representative IHC staining for PY-Stat3 (Tyr705), Ki67, keratin 16, or keratin 17 Abs in serial sections of psoriatic lesional skin or healthy controls. (c) The statistical analysis of IHC staining for PY-Stat3 (Tyr705), Ki67, keratin 16, or keratin 17 in psoriatic lesional skin or healthy controls. (d) Representative IHC staining for HO-1 or SHP-1 in serial sections of psoriatic lesional skin or healthy controls. (e) The statistical analysis of IHC staining for HO-1 or SHP-1 in serial sections of psoriatic lesional skin or healthy controls. Magnification: ×100. *represents P < 0.05, which indicates a statistically significant difference.

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