Figure 8: The diagram shows the Proposed Molecular mechanism of HO-1 mediated Stat3 inhibition. | Scientific Reports

Figure 8: The diagram shows the Proposed Molecular mechanism of HO-1 mediated Stat3 inhibition.

From: Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling

Figure 8

Persistent actived Stat3 promotes hyperproliferation and abnormal keratin expression in the keratinocytes of psoriasis patients, treatments with Hemin/CoPP induce HO-1 expression, which enhance the expression of SHP-1 in cell plasma, this result in the inhibition of Stat3 phosphorylation and the decrease of downstream genes expression.

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