Table 2 Cox Hazard Regression Analysis of Clinicopathologic Factors and the MET for Overall Survival in pGBM (n = 175).

From: Low c-Met expression levels are prognostic for and predict the benefits of temozolomide chemotherapy in malignant gliomas

Variable

Univariate analysis

Multivariate analysis

HR

95% CI

P

HR

95% CI

P

Sex

0.811

0.554–1.188

0.282

   

Age

1.020

1.005–1.034

 < 0.010

0.975

0.946–1.005

0.103

IDH1 mutation

0.580

0.316–1.067

0.08

   

MGMT promoter methylation

0.552

0.346–0.881

0.013

0.758

0.331–1.738

0.513

c-Met

1.640

1.115–2.412

0.01

2.389

1.126–5.072

0.023

KPS

0.973

0.955–0.991

 < 0.01

0.962

0.938–0.988

 < 0.01

Extent of resection

1.579

1.086–2.297

0.017

0.826

0.397–1.720

0.610

Radiotherapy

0.490

0.294–0.818

 < 0.01

0.478

0.199–1.150

0.099

Chemotherapy

0.387

0.262–0.569

 < 0.01

0.237

0.113–0.499

 < 0.01

  1. Abbreviations: pGBM, primary glioblastomas multiforme; IDH1, isocitrate dehydrogenase 1; MGMT, O6-methylguanine–DNA methyltransferase; KPS, Karnofsky Performance Status.
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