Figure 8
From: Multi-functionalized carbon dots as theranostic nanoagent for gene delivery in lung cancer therapy
Monitoring luciferase inhibition in vivo with bioluminescent imaging.
Representative images show the reduction in lung tumor size following intratracheal instillation of fc-rPEI-Cdots nanoagents in luciferase-expressing H460 lung carcinoma. Panels (A–C) depict bioluminescent images of the lungs before and after treatment. (B) 7 days, (C) 10 days after two times inhaled administration. After aerosol delivery, the fc-rPEI-Cdots/pooled siRNA nanoagents (D) can accumulated at lung region when compared to PBS (E).
