Figure 10: Gonadal white adipose depot features in CTL (placebo) and DHT-treated wild type mice and CMKLR1-deficient mice. | Scientific Reports

Figure 10: Gonadal white adipose depot features in CTL (placebo) and DHT-treated wild type mice and CMKLR1-deficient mice.

From: CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone

Figure 10

Adipose depots were isolated at the end of the 90-d treatment period. (A) Hematoxylin and eosin (HE)-stained section of gonadal adipose depots in placebo- and DHT-treated wild type mice and CMKLR1 null mice. Scale bar = 50 μm. (B) Adipocyte size measurement in placebo-treated and DHT-treated mice. In each group, the diameters of a total of 450 adipocytes were measured in three randomly selected sections per fat depot per mouse. Data represent mean ± SEM (n = 10 mice per group). Hematoxylin and eosin staining of CTL and DHT-treated gonadal white adipose depots. Increased adiposity upon chronic DHT treatment in wild type mice compared with placebo-treated wild type mice. Decreased adiposity in DHT-treated CMKLR1 null mice compared with DHT-treated wild type mice. (a) p, DHT-treated vs. control wild type mice; (b) p, DHT-treated vs. control CMKLR1-null mice; (c) p, vehicle-treated CMKLR1 null mice vs. vehicle-treated wild type mice; (d) p, DHT-treated CMKLR1 null mice vs. DHT-treated wild type mice.

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