Figure 12: Modulation of progesterone and estradiol biosynthesis in follicles with DHT treatment. | Scientific Reports

Figure 12: Modulation of progesterone and estradiol biosynthesis in follicles with DHT treatment.

From: CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone

Figure 12

The process of progesterone production requires the following enzymes: cholesterol side-chain cleavage cytochrome P450 (CYP11A1, P450scc), 3-βhydroxysteroid dehydrogenase (3βHSD), and steroidogenic acute regulatory protein (STAR). Thecal cells from rodents produce progesterone/testosterone as precursors for estradiol production in neighboring granulosa cells. Expression levels of genes encoding steroidogenic enzymes are regulated by many different factors within the antral follicle, including hCG, the stimulatory factors are shown in Green arrow. DHT treatment inhibits hCG induction through BMP4 pathway in red T shapes, while Chemerin stimulates the effect of DHT through its receptor, CMKLR1. hCG, Human chorionic gonadotropin. DHT, dihydrotestosterone. BMP-4, bone morphogenetic protein 4.

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