Figure 2: Ovarian features in CTL (placebo) and DHT-treated wild type and CMKLR1-deficient mice. | Scientific Reports

Figure 2: Ovarian features in CTL (placebo) and DHT-treated wild type and CMKLR1-deficient mice.

From: CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone

Figure 2

Hematoxylin and eosin staining of CTL and DHT-treated ovaries were observed. Both CTL wild type mice and CMKLR1 null mice display follicles at different stages and the presence of corpora lutea. DHT treatment results in shrinkage of the ovarian structure with minimal large antral follicles and the absence of corpora lutea in wild type mice, whereas DHT-treated CMKLR1-null mice contain a few follicles at different stages and corpora lutea. DHT-treated wild type ovaries contain condensed atypical follicles exhibiting absence of oocytes and reduced granulosa cell numbers. However, DHT-treated CMKLR1 null ovaries display more typical follicles and fewer atypical follicles. The symbol “*” represents CL: corpus luteum. Bar = 100 μm.

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