Figure 2: Effects of candidate interventions on radiation-induced increase of resorption-related genes.
From: Dried plum diet protects from bone loss caused by ionizing radiation
Mice were fed various diets or injected with DHLA or Ibuprofen, then irradiated with 137Cs (2 Gy). Dietary interventions included an antioxidant cocktail (AOX) or dried DP (25% by weight) and three separate control diets (Fig. 1 and Methods). After irradiation (24 hr + / − 20 min), mice were euthanized and bone marrow cells were collected for analysis of gene expression by qPCR. Y-axis values indicate relative expression levels of gene of interest normalized to Gapdh using the ΔCt method. Data shown are mean + S.D. (n = 5–6/group) and analyzed by 1-factor ANOVA. *indicates p < 0.05 compared to CD1/sham-irradiated controls by Dunnett’s post hoc test.
