Figure 9 | Scientific Reports

Figure 9

From: Three-Dimensional Characterization of Mechanical Interactions between Endothelial Cells and Extracellular Matrix during Angiogenic Sprouting

Figure 9

Experimental observations of the bead movement manifesting the interactions between a stalk cell (in green ellipse) and the ECM.

These two consecutive (T = 15 minutes) focused bright-field images were generated with 85 slices (with a step size of 0.75 um). The stalk cell migrated along the longitudinal axis of the lumen during the time lapsed between the two images. The beads (in ellipse) close to the stalk cell featured a similar movement to that of the cell, suggesting that there was a possibility that the stalk cell migration passively displaced the nearby region, called “migration-related push” herein. Those highlighted with circles slightly moved toward the stalk cell, showing the same “pull” behavior as that of the tip cells, but less pronounced.

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