Table 2 Cox Regression Model: Overall survival.

From: Clinical Relevance of Liver Kinase B1(LKB1) Protein and Gene Expression in Breast Cancer

 

NTUH

MMH

NTUH/MMH Summary Analysis

 

HR

95%CI

P

HR

95%CI

P

HR

95%CI

P

LKB1(IHC)

  

0.321

  

0.823

  

0.419

 Negative

1.000

  

1.000

  

1.000

  

 Positive

0.766

0.453–1.296

 

1.054

0.665–1.671

 

0.868

0.615–1.224

0.419

ER

  

0.001*

  

0.064

  

<0.0001*

 Negative

1.000

  

1.000

  

1.000

  

 Positive

0.369

0.210–0.648

 

0.620

0.374–1.028

 

0.523

0.365–0.748

 

HER2

  

0.233

  

0.247

  

0.211

 Negative

1.000

  

1.000

  

1.000

  

 Positive

0.690

0.375–1.269

 

0.753

0.466–1.217

 

0.790

0.547–1.142

 

T

  

0.193

  

<0.0001*

  

<0.0001*

 T1

1.000

  

1.000

  

1.000

  

 T2

1.657

0.910–3.016

0.098

0.732

0.424–1.263

0.262

1.169

0.785–1.742

0.442

 T3

2.114

0.838–5.334

0.113

1.901

0.820–4.404

0.134

1.716

0.951–3.096

0.073

 T4

2.881

0.811–10.232

0.102

3.499

1.502–8.150

0.004

3.976

2.038–7.757

<0.0001

N

  

0.007*

  

<0.0001*

  

<0.0001*

 N0

1.000

  

1.000

  

1.000

  

 N1

1.349

0.742–2.450

0.326

2.325

1.231–4.390

0.009

1.744

1.139–2.671

0.011

 N2

3.088

1.444–6.601

0.004

4.186

2.130–8.226

<0.0001

4.587

2.895–7.269

<0.0001

 N3

3.292

1.356–7.991

0.008

5.329

2.730–10.399

<0.0001

6.004

3.712–9.711

<0.0001

Grade

  

0.809

  

0.361

  

0.105

 Grade 1

1.000

  

1.000

  

1.000

  

 Grade 2

1.257

0.574–2.752

0.567

2.692

0.630–11.510

0.182

1.955

1.005–3.805

0.048

 Grade 3

1.327

0.557–3.161

0.523

2.946

0.668–13.002

0.154

2.127

1.051–4.306

0.036

Menopause

  

0.083

  

0.105

  

0.006*

 Negative

1.000

  

1.000

  

1.000

  

 Positive

1.586

0.941–2.674

 

1.501

0.918–2.453

 

1.631

1.149–2.317

 
 

METBRIC Discovery Cohort

METBRIC Validation Cohort

 

HR

95%CI

P

HR

95%CI

P

LKB1(mRNA)

  

0.512

  

0.816

 Negative

1.000

  

1.000

  

 Positive

0.937

0.772–1.138

0.512

1.024

0.839–1.250

0.816

ER

  

0.050*

  

0.080

 Negative

1.000

  

1.000

  

 Positive

0.770

0.593–1.000

 

0.794

0.613–1.028

 

HER2

  

0.008*

  

0.521

 Negative

1.000

  

1.000

  

 Positive

1.479

1.110–1.972

 

1.101

0.821–1.476

 

T

  

0.007*

  

<0.0001*

 T1

1.000

  

1.000

  

 T2

1.334

1.076–1.653

0.009

1.701

1.369–2.114

<0.0001

 T3

1.798

1.129–2.864

0.013

2.381

1.600–3.543

<0.0001

N

  

<0.0001*

  

<0.0001*

 N0

1.000

  

1.000

  

 N1

1.307

1.038–1.647

0.023

1.385

1.102–1.740

0.005

 N2

2.112

1.594–2.799

<0.0001

2.060

1.508–2.814

<0.0001

 N3

4.343

2.682–7.032

<0.0001

3.433

2.370–4.973

<0.0001

Grade

  

0.713

  

0.240

 Grade 1

1.000

  

1.000

  

 Grade 2

1.044

0.664–1.640

0.852

1.381

0.926–2.060

0.113

 Grade 3

1.134

0.719–1.788

0.590

1.411

0.937–2.124

0.099

Menopause

  

0.001*

  

0.008*

 Negative

1.000

  

1.000

  

 Positive

1.543

1.194–1.994

 

1.443

1.099–1.894

 
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