Table 3 Cox Regression Model: Breast Cancer Specific Survival.
From: Clinical Relevance of Liver Kinase B1(LKB1) Protein and Gene Expression in Breast Cancer
METBRIC Discovery Cohort | METBRIC Validation Cohort | |||||
|---|---|---|---|---|---|---|
HR | 95%CI | P | HR | 95%CI | P | |
LKB1(mRNA) | 0.856 | 0.282 | ||||
Negative | 1.000 | 1.000 | ||||
Positive | 0.977 | 0.761–1.255 | 0.865 | 0.665–1.126 | ||
ER | 0.054 | 0.021* | ||||
Negative | 1.000 | 1.000 | ||||
Positive | 0.726 | 0.524–1.005 | 0.680 | 0.490–0.943 | ||
HER2 | 0.003* | 0.056 | ||||
Negative | 1.000 | 1.000 | ||||
Positive | 1.669 | 1.186–2.348 | 1.393 | 0.991–1.959 | ||
T | 0.049* | <0.0001* | ||||
T1 | 1.000 | 1.000 | ||||
T2 | 1.316 | 0.991–1.747 | 0.058 | 1.709 | 1.271–2.299 | <0.0001 |
T3 | 1.841 | 1.051–3.223 | 0.033 | 2.287 | 1.390–3.761 | 0.001 |
N | <0.0001* | <0.0001* | ||||
N0 | 1.000 | 1.000 | ||||
N1 | 1.628 | 1.201–2.208 | 0.002 | 1.787 | 1.299–2.459 | <0.0001 |
N2 | 2.771 | 1.945–3.948 | <0.0001 | 3.223 | 2.163–4.803 | <0.0001 |
N3 | 5.483 | 3.057–9.836 | <0.0001 | 5.244 | 3.380–8.135 | <0.0001 |
Grade | 0.182 | 0.042* | ||||
Grade 1 | 1.000 | 1.000 | ||||
Grade 2 | 1.266 | 0.651–2.459 | 0.487 | 2.655 | 1.223–5.765 | 0.014 |
Grade 3 | 1.585 | 0.817–3.075 | 0.173 | 2.690 | 1.227–5.898 | 0.013 |
Menopause | 0.977 | 0.633 | ||||
Negative | 1.000 | 1.000 | ||||
Positive | 0.996 | 0.738–1.344 | 0.926 | 0.674–1.271 | ||
