Table 1 Top signaling pathways and their associated molecules.
Ingenuity canonical pathways | Molecules | |
|---|---|---|
Constitutive | Estrogen Receptor Signaling | TAF4B, THRAP3, TAF5, MED1, MED13L, MED4, TAF15 |
CD27 Signaling in Lymphocytes | MAP3K12, MAP2K7, IKBKG, IKBKAP | |
TNFR1 Signaling | IKBKG, MADD, XIAP | |
Protein Ubiquitination Pathway | DNAJC28, DNAJC24, UBR1, ANAPC5, UBE3A, XIAP, SKP2, DNAJC11 | |
AMPK Signaling | CAB39, PPP2R3A, STRADA, PPP2R2B, RPTOR | |
Temporal | IL-17A Signaling in Fibroblasts | FOS, JUN, NFKBIA, LCN2, CEBPD, CEBPB, NFKB2, IL6, NFKBIZ, MAPK11 |
IL-10 Signaling | IL33, FOS, IL4R, JUN, NFKBIA, IL1B, STAT3, IL1R1, NFKB2,IL6, FCGR2B, MAPK11 | |
IL-6 Signaling | IL6R, STAT3, IL1R1, CEBPB, NFKB2, IL6, MAPK11, IL33, FOS, NFKBIA, JUN,PIK3C3,IL1B,ATM,MCL1 | |
JAK/Stat Signaling | FOS, PIK3C3, PIAS1, CDKN1A, CISH, PTPN1, SOCS2, STAT3, IL6, STAT1, ATM | |
IL-9 Signaling | PIK3C3, CISH, SOCS2, BCL3, STAT3, NFKB2, STAT1, ATM | |
