Figure 1

HIV infection in HuMice co-infected with Mtb.

BLT HuMice were infected i.v. with 2,500 TCID₅₀ of HIV-1 (JR-CSF) or mock infected (PBS). Subsets of HuMice from HIV or non-infected mice were infected i.n. with 250 CFU Mtb (H37Rv), 3 wk post-HIV infection. Data are means ± SEM from samples of non-infected control (n = 4) and three infection groups, HIV (n = 3), Mtb (n = 6) and Mtb/HIV (n = 8), of HuMice. (A) HIV p24 capsid protein was detected in HuMouse spleen and plasma by ELISA at 8 and 5 wk p.i. with HIV and Mtb, respectively. Viral load did not differ among HIV and Mtb/HIV infection groups and results are thus pooled. (B) Flow cytometric detection of human CD45⁺CD3⁺CD4⁺T cells in peripheral blood, shown as a percent of baseline (pre-HIV infection) value at 5 wk p.i. with Mtb.