Figure 3
From: Pulmonary Tuberculosis in Humanized Mice Infected with HIV-1
Pulmonary growth of Mtb is increased by HIV co-infection prior to peripheral CD4+ T cell depletion.
(A) CFU enumeration of Mtb in lung and liver tissue of HuMice at 5 wk p.i. with Mtb from two independent studies. Statistically significant differences compared to non-infected are designated by *p < 0.05. (B) Increased bacterial growth confirmed by Ziehl-Neelson detection of AFB by light microscopy in representative lung of Mtb-infected (left) and Mtb/HIV co-infected mice (right). (C) Correlation between HIV p24 and mycobacterial proliferation or pathology in the lung of co-infected HuMice (n = 8) was determined using a Spearman’s rank correlation co-efficient (Rs).
