Figure 5
From: Pulmonary Tuberculosis in Humanized Mice Infected with HIV-1
Co-infection with HIV promotes neutrophil accumulation in pulmonary TB granulomas.
(A) Visualization of lung pathology due to Mtb infection and Mtb/HIV co-infection in reference human (top) and representative humanized mouse (bottom) lung, demonstrating diffuse lesions and tissue damage. (B), Determination of neutrophil accumulation due to Mtb or Mtb/HIV infection through detection of myeloperoxidase (MPO) in infected human (top) and HuMouse lung (bottom) tissue. Top inset shows non-specific control staining for fast red in the necrotic lesion. Bottom inset shows representative tissue from HuMouse with HIV mono-infection, demonstrating lack a paucity of neutrophils and non-remarkable pathology in the absence of Mtb co-infection.
