Table 1 Selected co-regulated genes for vimentin.
Co-regulated gene | Description (adopted from NCBI Gene) | Number of experiments | Percentage of concordance | Pearson coefficient | Pearson p-value |
|---|---|---|---|---|---|
Lectin, galactoside- binding, soluble, 1 (LGALS1) | Implicated in cell-cell and cell-matrix interactions, also pro-apoptotic. | 1852 | 88.012 | 0.595 | 5.128e-298 |
Reticulocalbin 1, EF-hand calcium binding domain (RCN1) | Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER | 1413 | 80.537 | 0.583 | 1.130e-282 |
Interferon induced transmembrane protein 3 (IFITM3) | It acts as an effector molecule for interferon-gamma, which is essential for anti-tuberculosis immune response | 1354 | 86.336 | 0.574 | 7.978e-272 |
Annexin A5 (ANXA5) | Binds cooperatively to phosphatidylserine on apoptotic cell membranes | 1473 | 92.328 | 0.570 | 4.417e-268 |
Transforming growth factor, beta receptor II (TGFBR2) | A receptor with Ser/Thr kinase activity | 1478 | 85.250 | 0.549 | 2.105e-244 |
Notch 2 (NOTCH2) | Regulates interactions between physically adjacent cells. | 1402 | 84.094 | 0.539 | 5.106e-234 |
G protein-coupled receptor 124 (GPR124) | A member of GPCR family | 1178 | 85.653 | 0.525 | 7.926e-220 |
Kruppel-like factor 2 (lung) (KLF2) | Regulates T-cell trafficking by promoting expression of S1P1 and the CD62L. | 1418 | 81.734 | 0.516 | 4.316e-211 |
Platelet-derived growth factor receptor, beta polypeptide (PDGFRB) | A cell surface tyrosine kinase receptor | 1509 | 82.571 | 0.486 | 3.984e-184 |
Transforming growth factor, beta receptor III (TGFBR3) | A membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptors. | 1551 | 80.141 | 0.453 | 1.323e-157 |
Mannose receptor, C type 2 (MRC2) | Important in extracellular matrix remodelling and in phagocytosis | 1417 | 81.016 | 0.453 | 4.953e-157 |
Prostaglandin I2 (prostacyclin) synthase (PTGIS) | Associated with inflammation in atherosclerosis | 1500 | 77.466 | 0.446 | 7.145e-152 |
Chemokine (C-C motif) ligand 2 (CCL2) | This cytokine displays chemotactic activity for monocytes and basophils | 1357 | 78.555 | 0.430 | 3.820e-140 |
Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) | This receptor can activate NF-kappaB, mediate apoptosis and function as a regulator of inflammation. | 1131 | 79.929 | 0.389 | 3.161e-113 |
Fc fragment of IgG, receptor, transporter, alpha (FCGRT) | A receptor that binds the Fc region of monomeric immunoglobulin G. | 1416 | 73.658 | 0.384 | 4.921e-110 |
Protein kinase C, delta binding protein (PRKCDBP) | A binding protein of the protein kinase C, delta | 1256 | 78.662 | 0.382 | 1.718e-108 |
Interleukin 6 (IL6) | Causes acute and chronic inflammation | 1079 | 84.059 | 0.369 | 3.657e-101 |
Complement component 1, s subcomponent (C1S) | A serine protease and constituent of the human complement subcomponent C1 | 1677 | 75.074 | 0.366 | 2.447e-99 |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA) | A member of the NF-kappa-B inhibitor family, which contains multiple ankrin repeat domains. | 1314 | 76.331 | 0.356 | 1.192e-93 |
Complement component 1, r subcomponent (C1R) | The first protease activated in the classical complement pathway | 1323 | 78.155 | 0.355 | 3.442e-93 |
Tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) | This gene can be induced by tumor necrosis factor alpha and interleukin-1 | 1153 | 78.577 | 0.349 | 7.049e-90 |
Calumenin (CALU) | A calcium-binding protein localized in the endoplasmic reticulum | 1166 | 80.102 | 0.348 | 1.922e-89 |
