Figure 1: Gene expression analysis of 17 patient-derived GSCs identifies two distinct clusters. | Scientific Reports

Figure 1: Gene expression analysis of 17 patient-derived GSCs identifies two distinct clusters.

From: Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome

Figure 1

(A) Hierarchical clustering of GSCs using the top 1,000 most variable genes/probes in our gene expression datasets. (B) Hierarchical clustering of GSCs using a subset of the genes/probes in A, selected among the highest-score Gene Sets resulting from GSEA on genes/probes differentially regulated between Cluster 1 and Cluster 2. The colored left-side bar annotates the correspondent Gene Sets clusters. (C) Hierarchical clustering of the top 1,000 most variable common genes found in our GSC (yellow and brown rectangles) samples and in Schulte GSr/GSf (grey and black rectangles) samples. Heatmaps throughout the figure display differences in expression levels in log2 scale (red + 3, black = 0, green = −3).

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