Figure 2: 1D1H NMR distinguishes two metabolic profiles of GSCs.
From: Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome
(A) Unsupervised clustering of GSCs based on the levels of the analyzed metabolites. Samples are annotated with their matching gene expression clusters (colored boxes on the left) with the exception of sample #112. (B) GSr-/GSf-like ratios of NMR signal intensity means were converted to log2 and expressed as fold change (FC). Metabolites displaying a statistically significant (p < 0.05, Student’s t-test) difference between GSr- and GSf-like are indicated by asterisks. (C) Boxplots of raw NMR signal intensities of metabolites measured in GSf-like (cluster 1, yellow) and GSr-like (cluster 2, brown) samples.
