Figure 3: Phosphoproteomic analysis supports genomic and metabolic clustering of GSCs.
From: Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome
Boxplots of standardized levels of selected RPPA analytes displaying a statistically significant (p < 0.05, Wilcoxon rank sum test) difference between GSCs of GSr- or GSf-like gene expression cluster. Based on the absolute difference between RPPA levels measured in GSr- and GSf-like GSCs, endpoints were divided in two groups, i.e. GSr-like (brown, high in GSr-like) and GSf-like (yellow, high in GSf-like), respectively. RPPA endpoints are sorted in descending order starting from the one showing the highest levels in GSr-like GSCs. Each antibody is annotated (right side) with the corresponding p value. Outliers are shown as circles and names of the major pathways defining GSr- or GSf-like cells are reported for both clusters.
