Figure 3
Transcriptional responses of circadian rhythm (CRN) genes in eyes of zebrafish.
(A) Proportion of genes with altered transcriptional responses in females to various concentrations of P4 (upper) and DRS (lower) presented in colors and numbers of gene transcripts. Blue: numbers of genes without significant alterations. Red: numbers of up-regulated genes. Green: numbers of down-regulated genes. (B) Different types of transcriptional responses expressed as fold-changes compared to unexposed (normal) females sampled at the same time-point. Blue bars in each figure represent gene expressions of unexposed (normal) females. Red bars in each figure represent gene expressions of exposed females; C, solvent control and P4 and DRS-exposed. (C) Proportion of genes with altered transcriptional responses in males to various concentrations of P4 and DRS presented in colors and numbers of gene transcripts. (D) Different types of transcriptional responses expressed as fold-changes compared to the unexposed (normal) males sampled at the same time-point. Key for concentrations (red bars): P4: L: low dose (7 ng/L); M: middle dose (116 ng/L); H: high dose (742 ng/L). DRS: L: low dose (99 ng/L); M: middle dose (2´763 ng/L); H: high dose (13´650 ng/L).
