Figure 6: Hippocampal amyloid-beta plaque burden significantly increases in B6.APBTg mice fed the western diet. | Scientific Reports

Figure 6: Hippocampal amyloid-beta plaque burden significantly increases in B6.APBTg mice fed the western diet.

From: Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease

Figure 6

(A–C) Assessment of plaque number using Thioflavin S (ThioS, blue) of the hippocampus showed a significant increase in plaque number in the hippocampus of B6.APBTg mice fed a western diet (B) compared to a control diet (A) (p = 0.0008, n = 4, C). (D) Interestingly, this increase was not observed in the cortex (p = 0.5, n = 4). (E,F) The region specific increase in plaque burden was confirmed by measuring Aβ42 levels (by ELISA) that showed a significant increase in Aβ42 levels in the hippocampus (E, P = 0.464, n = 6), but not the cortex (F, P = 0.78, n = 6) of B6.APBTg mice fed the western diet (E) compared to the control diet (F). Scale bars: 160 μm.

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