Figure 4 | Scientific Reports

Figure 4

From: Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors

Figure 4

Molecular tension measurement on cadherin and integrin.

(A) Schematics of Ecad immobilization through 12–54 pN ProG-based TGTs for cadherin tension measurement. (B) DLD-1 cells adhered on all 12~54 pN Ecad-Fc:ProG-TGT coated surfaces. (C) Cell adhesion density vs. Ttol. (D) Schematics of RGDfK-Fc immobilization through 12–54 pN ProG-based TGTs for integrin tension measurement. (E) Phase-contrast images of CHO-K1 cell adhesion on 12~54 pN RGDfK-Fc:ProG-TGT coated surfaces. (F) Cell adhesion density vs. Ttol. Scale bar: 100 μm.

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