Figure 2 | Scientific Reports

Figure 2

From: Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis activates Akt signaling to ameliorate hepatic steatosis

Figure 2

ACE2 regulated hepatic gene expressions involved in lipid-metabolizing, oxidative stress and inflammation in the liver of ACE2−/y mice.

(A) Relative protein levels of lipid-metabolizing (ACCα, SREBP-1c, LXRα, FAS, AdipoR1 and UCP-2). (B) Relative gene expression levels of fatty acid oxidation-related genes (PGC-1α, CPT-1α, PPARα, PPARγ and MCAD). (C) Relative protein levels of oxidative stress signaling (catalase, GPX1 and SOD2) and (D) inflammation (TNF-α, MCP-1 and IL-8). The data are presented as the mean ± SD of n = 4 independent experiments in ACE2−/y mice. *P < 0.05 and **P < 0.01 versus WT mice by Student’s t test.

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