Figure 3 | Scientific Reports

Figure 3

From: Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis activates Akt signaling to ameliorate hepatic steatosis

Figure 3

Hepatic overexpression of ACE2 ameliorated hepatic steatosis of db/db mice.

(A) Representative images of liver sections from db/db, db/db + GFP and db/db + ACE2 mice stained with Oil-Red-O. Quantitative assay of (B) AngII, (C) triglyceride and cholesterol, (D) ALT and AST levels in ACE2-overexpressing db/db mice. *P < 0.05versus db/db + GFP mice (n = 6). (E) Relative gene expression levels of fatty acid oxidation-related genes (PGC-1α, CPT-1α, PPARα, PPARγ and MCAD). *P < 0.05 versus db/db + GFP by Student’s t test.

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