Figure 1 | Scientific Reports

Figure 1

From: Drug activity screening based on microsomes-hydrogel system in predicting metabolism induced antitumor effect of oroxylin A

Figure 1

In vitro antitumor activity screening of OA and W through MHCCS.

(a–d) Cytotoxicity profiles of OA and W incubated through TCCS or MHCCS in MCF-7, PANC-1, HCC827 and HuH-7 cells were determined by MTT assay respectively. (e) Cytotoxicity profiles of OA, OA and NADPH, OA incubated through MHCCS in MCF-7 cells were determined by MTT assay respectively. Data were expressed as mean ± S.D. (n = 5). (f,g) OA induced apoptosis in MCF-7 cells through TCCS or MHCCS. Quantitative results using flow cytometry, with the Y-axis showing PI labeling and the X-axis showing FITC-labeled Annexin V positive cells (f). (g) was the statistical analysis of total apoptosis cells. Data were expressed as mean ± S.D. (n = 3). Data were statistically analyzed by one tail unpaired T-test. *P < 0.05, **P < 0.01, ***P < 0.001.

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