Figure 1 | Scientific Reports

Figure 1

From: Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development

Figure 1

(a) Structural model of the influenza A virus (H1N1) nucleoprotein (NP). The 13 conserved residues that were substituted by alanine to analyze RNA-binding ability are marked. (b) Surface representation of the homology model of the influenza A virus (H1N1) NP: electrostatic potentials are blue (positive) or red (negative). (c) Amino acid pairwise sequence alignment of the NPs of the H1N1 strain (A/HUMAN/TW/2001), (A/SWINE/NO/2009), H5N1 (A/CHICKEN/HK/2002) and H3N2 (CANINE/CN/2010). Tyrosine (Y), arginine (R) and lysine (K) that were substituted by alanine are highlighted with red and blue, respectively and indicated with triangles.

Back to article page